Knight says that the method of transmission that Collinge identified is “extremely unusual,” and there’s no evidence that ...

Interestingly, the extended PMCA yielded novel forms of misfolded prions that caused new disease phenotypes. When injected into wild-type hamsters, the PMCA-generated hampster PrP Sc caused ...

which can distinguish prion disease from other causes of rapidly progressive dementia—particularly autoimmune forms of dementia and rapidly progressive forms of Alzheimer's disease. "Rapidly ...

A silent but deadly epidemic is creeping through North America and scientists are sounding the alarm.

But sometimes, prions can also be transmitted from one individual to another (infamously, the prion disease kuru was spread through cannibalism), or even between two different species of animal.

While prion disorders like Creutzfeldt-Jakob disease are vanishingly rare in humans, studying these conditions could provide important insights into more common diseases that involve protein ...

May 17, 2024 — A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD ...

Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both ...

Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases that include bovine spongiform encephalopathy (BSE), scrapie in sheep, and Creutzfeldt–Jakob disease ...

Led by a team at the Broad Institute, the new gene therapy aims to address the root cause of prion disease by using the CHARM (Coupled Histone tail for Autoinhibition Release of Methyltransferase) ...