Knight says that the method of transmission that Collinge identified is “extremely unusual,” and there’s no evidence that ...

Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both because it is difficult to treat and because of its high mortality rate. In ...

为了了解朊病毒在癌症生物学中的重要性，首先需要了解GBM的作用机制。正如Lopes所解释的那样，手术和替莫唑胺治疗会杀死快速增殖并形成肿瘤“团块”的细胞。然而，所谓的肿瘤干细胞（胶质母细胞瘤干细胞）在脑组织中仍然处于休眠状态。当它们再次活跃时，它们能够再次协调肿瘤生长。

Durable analytical instruments expedite the study of misfolded proteins linked to neurodegenerative diseases. To overcome these limitations, scientists developed the real-time quaking-induced ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report ‘seeding’ this accumulation through fragments of the culprit ...

Dysfunctional Family. A family tree of tau folds now incorporates two new structures—P301L, P301T (bottom)—and fills in ...

A silent but deadly epidemic is creeping through North America and scientists are sounding the alarm.

The disease involves the formation of pathological deposits of protein in the brain. The protein responsible, the non-infectious cellular isoform of prion protein (PrPC), can adopt an aberrant ...

In a study published in Neuron, researchers report 'seeding' this accumulation through fragments of the culprit protein created in the lab. The findings provide further evidence for a prion-like ...