Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive ...

Scientists at the Faculty of Medicine have now developed an innovative numbering system for the GAIN domain, a protein domain common to all adhesion GPCRs. It should help to elucidate the role of ...

Using the CRISPR/Cas9 genome-editing system to mutate the gene regions encoding particular protein domains could result in a new and more efficient method to screen for druggable protein targets ...

People with inflammatory bowel disease (IBD) also have an increased risk of developing colorectal cancer. However, the exact ...

Glyoxalase Domain-containing Protein 4 (GLOD4), the First Identified in a New Class of Enzymes Called Nitrases, Generates Nitrated ...

Metabolic reprogramming in cancer involves glycolytic enzymes acquiring noncanonical functions and acting as protein kinases, which contribute to tumor progression and present new therapeutic ...