A process as intricate as brain development requires precisely controlled expression of crucial genes, but it’s the different flavors of a protein, or isoforms, that the genes encode that do the heavy ...

Streicher and his team also tested the drug combination in a chronic pain model in mice. Three weeks after injection of an HIV protein, which induces peripheral neuropathy, the team treated the mice ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

“The field has been hampered by antibodies that recognize the wrong (or multiple) protein isoforms and antibodies that don’t work well in particular applications,” says Andrew ...

See Feil et al. (1997) BBRC. MAPT: Microtubule-associated protein tau, Axonally-localized microtuble stabilizing protein. Alternate splicing leads to 6 protein isoforms in human (containing 3- or ...

These isoforms are produced through alternative ... By identifying 1N4R tau as a key protein, we have discovered a potential ...

A new study has shed light on the complex interactions between dystrophin, a protein critical to muscle ... with the two ...