One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

ALPK3 (α protein kinase 3) is an atypical kinase highly expressed in human and murine hearts. Biallelic loss‐of‐function mutations in ALPK3 lead to pediatric cardiomyopathy. The specific stages at ...

John Scott’s principal contribution was the discovery of AKAP signaling complexes that cluster the broad specificity signaling enzyme protein kinase A (PKA) with additional enzymes at defined ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

Late-stage pipeline products anticipated to reach the uveitis market during the forecast period will introduce new mechanisms ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

Arvinas is continuing its investigation of arv-102 in neurodegenerative diseases associated with lrrk2 and lysosome ...

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in ...