To achieve higher sensitivity and a compact, easily manufacturable sensor structure, this article uses a single-mode optical fiber with a dual fiber Bragg grating (FBG) to form a Fabry-Pérot (FP) ...

In 1998, a protein structure that had not yet been experimentally observed was designed from scratch. 27 years later this work still demonstrates the power of a field that is undergoing an ...

That workaround often involves RAD52 — a protein now squarely in the sights of researchers hunting for new anti-cancer drugs. A new study published in Nature reveals an unexpected structure ...

The application of deep learning algorithms in protein structure prediction has greatly influenced drug discovery and development. Accurate protein structures are crucial for understanding biological ...

Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China ...

MULAN uses the pre-trained base PLM and has the Structure Adapter – a module we introduce to incorporate the knowledge about the 3D protein structure. Our model uses ESM-2 architecture, initializing ...

All the residues are depicted as spheres on the protein structure. The core residue for each community is highlighted in red, while purple is used to emphasize the secondary core residue. Residues ...

S7). Furthermore, DyNoPy also detected several previously unexplored Ω-loop residues. Community 1 and 2 of PDC-3 β-Lactamase. All the residues are depicted as spheres on the protein structure. The ...

College of Food Science and Engineering, Shandong Agricultural University, Tai’an, Shandong 271018, China Engineering and Technology Center for Grain Processing in Shandong Province, Tai’an, Shandong ...

solving a decades-long mystery by determining the first structure of the human protein PINK1 bound to mitochondria. First discovered more than 20 years ago, PINK1 is a protein directly ...

Figure 1: a, Ribbon diagram of the structure ... of apical domain proteins on rhodanese reactivation by GroEL/GroES. Figure 6: Rhodanese folding within the GroES-enclosed cavity of GroEL and ...

These bonds are dynamic, rapidly forming and breaking over time as the protein folds. Because it only takes nanoseconds to microseconds for a protein to morph along its path to its final structure, ...