为探究青蒿琥酯（ART）能否通过下调 NLRP3 改善脑小血管病（CSVD）大鼠学习记忆功能，研究人员建立 CSVD 大鼠模型开展研究。结果发现 ART 可改善大鼠认知障碍，下调相关炎症因子，NLRP3 或可成为潜在治疗靶点，为 CSVD 治疗提供新思路。

Their results highlight a previously unknown mechanism that amplifies UC symptoms. The study revealed that EBV infection dramatically increases the levels of pyroptosis-related proteins, including ...

A recent study has revealed how Epstein-Barr virus (EBV) intensifies ulcerative colitis (UC), a debilitating inflammatory bowel disease. Researchers discovered that EBV infection triggers macrophage ...

Ulcerative colitis (UC) is a chronic, relapsing disease that causes painful inflammation and ulcers in the colon. While its ...

These protective effects were mechanistically linked to the suppression of hepatocyte pyroptosis, as PEITC effectively reversed the upregulation of the NLRP3 inflammasome, Caspase-1 cleavage, and ...

The study revealed that EBV infection dramatically increases the levels of pyroptosis-related proteins, including Gasdermin D, NLRP3, interleukin-1β (IL-1β), and interleukin-18 (IL-18), in the ...

School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences ...

针对所提出的质疑，尚未见到作者在www.pubpeer.com上的回应内容。 平台声明：该文观点仅代表作者本人，搜狐号系信息发布平台，搜狐仅提供信息存储空间服务。

当 NLRP3 炎性小体被激活后，会促使白细胞介素 - 18（IL-18）和白细胞介素 - 1β（IL-1β）等固有细胞因子成熟。这些细胞因子的产生启动了神经炎症信号传导，同时诱导一种特殊的炎症性细胞死亡方式 —— 细胞焦亡（pyroptosis）。 在神经元受损的情况下，细胞内会 ...