接着，研究人员探究了棕榈酰化是如何促进炎症小体形成的。通过活细胞显微镜观察，他们发现，受到 NLRP3 激活剂刺激后，NLRP3 会迅速在细胞质中形成具有动态、液体样行为的斑点，这和液 - 液相分离（LLPS）的特征相符。而且这个过程完全依赖于棕榈酰化，没有棕榈酰化的 NLRP3 无法形成斑点，也不能支持炎症小体激活。

细胞焦亡：炎性细胞死亡的新方式 细胞焦亡（Pyroptosis）是一种新型的炎性细胞死亡模式 ... 会激活一系列的信号转导通路。其中，NOD 样受体蛋白 3（NLRP3）炎症小体的激活是细胞焦亡启动的关键环节之一。当细胞受到刺激后，NLRP3 会与凋亡相关斑点样蛋白 ...

The study revealed that EBV infection dramatically increases the levels of pyroptosis-related proteins, including Gasdermin D, NLRP3, interleukin-1β (IL-1β), and interleukin-18 (IL-18), in the ...

The study revealed that EBV infection dramatically increases the levels of pyroptosis-related proteins, including Gasdermin D, NLRP3, interleukin-1β (IL-1β), and interleukin-18 (IL-18), in the ...

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3 ... infection activates pyroptosis—a form of ...

Chimeric antigen receptor (CAR) T cells, engineered to track down and destroy cancer cells, induce pyroptosis, a messy form of cell death that causes the cells to explode, the researchers found. This ...