Tucidinostat is a subtype-selective histone deacetylase (HDAC) inhibitor that explicitly inhibits Class I and II (112 ... Since the resistance route may be linked to Rb1 deletion, over-activation of ...

CS1 is a new formulation of valproic acid that inhibits histone deacetylase (HDAC). Sten R. Sörensen, the company’s CEO, noted that the therapy has long been used to treat epilepsy. However, he said ...

INDIANAPOLIS — As the NFL scouting combine wrapped Sunday afternoon, league coaches, executives and scouts traveled home with notebooks full of 40-yard dash times and drill results, physical ...

为提升 HDR 相关基因编辑效率，研究人员筛选化合物，发现 HDAC 抑制剂有效，为基因编辑提供新策略。 基因编辑技术近年来在生命科学领域掀起了一阵 “变革之风”，其中 CRISPR-Cas9 系统凭借其独特优势备受瞩目。CRISPR-Cas9（成簇规律间隔短回文重复序列 / CRISPR ...

Other innovative approaches include conditional replicating oncolytic adenovirus targeting the RB1 pathway, which is currently under Phase I evaluation with promising early results. In the present ...