Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA ...

In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases. These RNA molecules, which do not encode proteins, ...

RNA-binding proteins play vital roles in tumor progression ... metabolism and hypoxia responses (21), MPHOSPH10 and MAP2K6 have received comparatively less attention in breast cancer. MPHOSPH10, a ...

We are in the midst of an RNA revolution, set to change the future of medicine. However, that revolution is now in jeopardy. The Yeo lab focuses on the function and therapeutic applications of RNA, a ...

including small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA). Significant numbers of small nucleolar RNAs (snoRNAs) are found in the nucleoli of eukaryotic cells. These small non-coding ...

and offers potential therapeutic targets in melanoma that are focused on reducing aSyn-mediated nucleolar double strand break repair," the authors conclude.

The MacDiarmid Institute for Advanced Materials and Nanotechnology, School of Chemical and Physical Sciences, Victoria University of Wellington, P.O. Box 600, Wellington 6140, New Zealand ...

结果发现硫酸乙酰肝素蛋白聚糖（HSPGs）等参与 LNP 摄取等过程，TRIM25 可抑制 mRNA，N 1 - 甲基假尿苷修饰能逃避其抑制。该研究为 RNA 免疫和疗法提供新思路。 外源性核糖核酸（RNAs），包括治疗性信使核糖核酸（mRNAs）和病毒核糖核酸，要进入细胞并合成蛋白质 ...