The chimeric fusion oncogene early B-cell factor 1–platelet-derived growth factor receptor-β (EBF1-PDGFRB) is a recurrent lesion observed in Philadelphia-like B-acute lymphoblastic leukemia (B ...

By elucidating its interaction with RUNX1, we can now envision therapeutic strategies that target this axis across diverse AML subtypes. The discovery of JMJD1C's role in AML cell survival opens a new ...

GA, UNITED STATES, March 3, 2025 /EINPresswire.com/ -- A new study has identified a critical mechanism that could lead to substantial advancements in the treatment of ...

Treatment stratification in ALL includes diverse (cyto)genetic aberrations, requiring diverse tests to yield conclusive data. We optimized the diagnostic workflow to detect all relevant aberrations ...

Chronic myelomonocytic leukemia is a rare hematopoietic malignancy characterized by persistent monocytosis in peripheral blood and bone marrow dysplasia.

This month's cover highlights the article Boosting human immunology: Harnessing the potential of immune organoids by Dirk Baumjohann and Maximilian Moll. The review article explores recent advances in ...

Background: N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin widely used to induce PD models, but the effect of MPTP on the cells and genes of PD has not been fully elucidated.

To enable cells to respond and adapt to their environment, they must be able to receive and process information (or "signals") that originate outside of the cell. Cell signaling – also sometimes ...

Resistance to therapy is the major hurdle in the current cancer management. Cancer cells often rewire their cellular process to alternate mechanisms to resist the deleterious effect mounted by ...

Developing neurons in the peripheral nervous system (PNS) are critically dependent on target-derived trophic cues released by the end organs they innervate. This is best exemplified for primary ...