The following is a summary of “METTL3-mediated methylation of RAC2 contributes to cell motility, oxidative stress and inflammation in TNF‐α-stimulated rheumatoid arthritis fibroblast-like synovial ...

为解决类风湿关节炎（RA）治疗靶点问题，山西医科大学第一医院研究人员开展 METTL3 对 RAC2 的 m?A 甲基化调控在 RA 中作用的研究，发现其促进 RA 进展，该成果为 RA 治疗提供新方向，值得科研读者一读。 类风湿关节炎（Rheumatoid arthritis，RA）是一种常见的慢性 ...

We therefore used a reconstituted cell-free NADPH oxidase system to examine the role of Rac2 in the electron-transfer reactions necessary for the generation of superoxide anion. We show that Rac2 ...

These inflammatory processes likely promote VSMC migration in a LIMK-dependent manner. Whether inflammatory cytokines activate LIMK via Rac2 activation remains unknown. (PDFG-BB: Platelet derived ...

The protein called Family with sequence similarity 49 member B (in short Fam49b) is a newly discovered negative regulator of TCR signaling that suppresses Rac-1 activity in vitro. The present ...

Specific cell shapes are fundamental to the organization and function of multicellular organisms. Fibroblast Growth Factor (FGF) signaling induces the elongation of lens fiber cells during vertebrate ...