Furthermore, the emerging idea that glial cells can act as multipotent progenitors seems to be true not only in the CNS, but also in the PNS, as SCPs, like radial glia, can give rise to unexpected ...

The goal is to have these cells then develop into neurons and glial cells, which support and protect neurons. In an announcement last week, the research team led by Keio University stem cell ...

Mechanistic Insights: The study offers valuable mechanistic insights into the development of microcephaly by elucidating the role of Abba in radial glial cell proliferation, radial fiber organization, ...

The oncogenic mechanisms by which TFE3 fusion proteins drive translocation renal cell carcinoma (tRCC) are poorly characterized. Here, we integrated loss and gain of function experiments with ...

None of these abnormalities were observed in hCOs generated by mixing only WT or only KO (modeling male carrier) cells. Discussion: Our results using the mosaic PCE hCO model suggest that PCDH19 plays ...

The team then ran the same test on ferrets, the brains of which more closely resemble a primate’s because they have folds and “have more basal radial glia to start with,” she adds. Once again, the ...

Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.

Nuclear Envelope Integrity: the proteins of this group affect the proper spindle alignment and cell fate determinants during NPC proliferation and protect radial glial cell (RGC) nuclei from ...

Neural activity has been implicated in the motility and outgrowth of glial cell processes throughout the central nervous system. Here, we explore this phenomenon in Müller glia, which are specialized ...