实现了减少（Reduction）、替代（Replacement）、优化（Refinement）的 3R 伦理原则。 肝细胞被分离后，可进行贴壁（Plateable）培养和悬浮(Suspension)培养。悬浮培养的原代肝细胞在最开始的4h内细胞色素P450酶的活性最为和体内一致，随时间的延长而迅速下降；贴壁培养 ...

Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands ...

Researchers at Germans Trias i Pujol Research Institute (IGTP) have led a study that evaluates, for the first time, the difference between sexes in advanced liver disease in a rat model.

Many of these methods rely on fixed or global proposal learning strategies, which lack a more refined method to improve localization accuracy. In this paper, we propose BRTAL, a new Boundary ...

COMMENT | At about 4.30 am, two plainclothes policemen jumped over the gates of former journalist Sidek Kamiso’s house and banged on the door, demanding entry. The two could not produce an ...

JOHOR BAHRU, March 8 — The public has been reminded to avoid touching on sensitive issues related to religion, race, and royalty (3R) on social media, as they could disrupt national peace. Dewan ...

BANTING: The police do not practise favouritism or double standards in investigating cases related to race, religion and royalty (3R), says Home Minister Datuk Seri Saifuddin Nasution Ismail (pic).

Department of Clinical Pharmacy, Jagiellonian University, Medical College, 9 Medyczna Street, 30-688 Kraków, Poland ...

3R' stands for "Reduce, Refine, Replace": the number of animals per experiment is reduced to the absolute minimum ('Reduction'); the performance of the experiments and the keeping of the animals ...

Background: Pelargonic acid vanillyl amide (PAVA), a stable synthetic analog of capsaicin, exhibits potential for therapeutic applications; however, it may present cytotoxic and pro-inflammatory risks ...