Not surprisingly, mRNA-stability determinants are found predominantly in the 3′ UTR where protein complexes are sheltered from traversing ribosomes, but they are also found in the 5′ UTR and ...

Only recently has the ribosome—one of the oldest molecular machines in evolutionary terms—been recognized as an active ...

The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...

The research field of "cellular IRESes" lay dormant for decades, as there was no uniform standard of reliable methods for the ...

Following the COVID-19 pandemic, mRNA-based vaccines have been shown to provide rapid and precise immune responses, however, this technology has much wider applications. Many leading pharma and ...