Ritonavir binds with CYP3A4 enzymes, which are responsible for metabolism, and gives nirmatrelvir a pharmacokinetic, or PK, boost. Unfortunately, ritonavir can also boost the lifetime of other ...

St. John’s wort may speed up the activity of an enzyme in your body called cytochrome P450 3A4 (CYP3A4). This enzyme helps break down Gleevec. By speeding up this enzyme, St. John’s wort can ...

This enzyme is called cytochrome p450 3A4 (CYP3A4). By slowing CYP3A4, these antifungals can cause Verzenio to build up in your body. This can increase your risk of Verzenio side effects.

An inter-species difference was observed as well, with faster rates of EA and EB hydrolysis in rat liver microsomes. Furthermore, our findings confirmed EA and EB were metabolized by multiple ...

Background: Dipeptidylpeptidase-4 inhibitors (DPP-4i′s) are considered to be safe for patients with type 2 diabetes mellitus (T2DM). However, little is known about drug–drug interactions between ...