The major histocompatibility complex (MHC) is a cluster of genes encoding molecules that are important for lymphocyte activation. MHC molecules bind small fragments of proteins from inside a cell ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. We aimed to restore MHC-I expression on the ...

The widely-accepted free radical theory of aging (FRTA) proposes that the accumulation of oxidative damage caused by reactive oxygen species (ROS) is one of the primary causes of aging. To define the ...

研究发现，NCF4通过调节细胞内活性氧（ROS）水平，影响单核吞噬细胞中半胱氨酸肽段的氧化状态，进而调节抗原呈递和致关节炎性T细胞的激活。 此外，免疫肽组学挖掘揭示了1型糖尿病中的新靶点。研究发现，内质网应激（ERS）重塑了β细胞的MHC-I相关免疫肽组 ...

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells do not express ...

De-extinction, the science of resurrecting extinct species, is progressing in leaps and bounds. Here are six creatures that researchers could bring back to life — and one they've already revived.

Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa 50011, United States Microelectronics Research Center, Iowa State University, Ames, Iowa 50011, United States ...

CD80；CD86；CD68；MHC-II，IL-1R,TLR-2,TLR-4,iNOS, IL-10 low, IL-12 high TNF-a,IL-1β，IL-6，IL-12，IL-23，1L-27，CXCL9，CXCL10，CXCL11，CXCL16,CCL5,；Arg2(mouse),iNOS(mouse),ROS。 CCL22，CCL24。 CCL1。 CXCL13。

Apr. 8, 2025 — The idea that dinosaurs were already in decline before an asteroid wiped most of them out 66 million years ago may be explained by a worsening fossil record from that time rather ...

黑素细胞表达的 MHC - II 分子，可以将处理后的抗原呈递给 T 淋巴细胞 ... 氧化应激是指细胞内活性氧（Reactive Oxygen Species，ROS）产生过多或抗氧化防御系统功能下降，导致氧化与抗氧化平衡失调的状态。黑素细胞在正常代谢过程中会产生一定量的 ROS，当受到 ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...