Array Bridge is testing promising drug candidates that can effectively bind and even degrade target proteins, but not via their active sites.

These phosphotyrosine interaction domains have three distinct biological roles: (i) recruiting SH2 or PTB domain-containing proteins to tyrosine-phosphorylated and activated receptor tyrosine ...

The IR bound IRS-1 is then itself tyrosine phosphorylated, creating a binding site for the SH2 domain of the adapter protein Grb2. The two SH3 domains of Grb2 bind proline rich motifs in the C ...