In contrast to PTB domains, the structurally distinct SH2 domains are highly specialized for the recognition of pTyr. Specificities of binding for individual SH2 domains can in many cases be ...

The IR bound IRS-1 is then itself tyrosine phosphorylated, creating a binding site for the SH2 domain of the adapter protein Grb2. The two SH3 domains of Grb2 bind proline rich motifs in the C ...