PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Collaborative Innovation Center for Modern Grain Circulation and Safety, Jiangsu Province Engineering Research Center of Edible Fungus Preservation and Intensive Processing, College of Food Science ...

研究人员为探究 GBP5 在炎症性肠病（IBD）中的促炎机制，发现 GBP5 通过增强 STAT1 活性促炎，为 IBD 治疗提供新靶点。 炎症性肠病（Inflammatory Bowel Diseases，IBD），包括克罗恩病（Crohn’s Disease，CD）和溃疡性结肠炎（Ulcerative Colitis，UC），是一种令人困扰的肠道疾病。

Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, ...

接下来，研究团队探讨了vitcylation在细胞内的功能。通过对肿瘤细胞进行vitC处理，作者发现vitC处理显著上调干扰素（IFN）通路基因（图3A, 3B），vitcylation显著增强了STAT1的磷酸化水平（图3E, 3F）。STAT1是干扰素（IFN）信号通路中的关键转录因子，其磷酸化水平直接 ...

This interaction is maintained after IFN stimulation. RACK-1 is a scaffold protein with no enzymatic activity, which recruits specific signaling elements. RACK-1 directly interacts with IFNAR2, TYK2, ...

Positive correlations were found between STAT1 and IRF9 with Siglec-1 (CD169), an IFN signature marker expressed on the surface of CD14+ monocytes ... to a personalized approach for this specific ...

Medicare Plan G is a Medigap policy that helps cover some out-of-pocket costs associated with Original Medicare (Parts A and B). “Medigap” is another term for Medicare supplement insurance.

We are entering an era of medicine where increasingly sophisticated data will be obtained from patients to determine proper diagnosis, predict outcomes and direct therapies. We predict that the most ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. As a common and severe cerebrovascular disease ...

Multiple signaling pathways are engaged by the type I and II IFN receptors, but their specific roles and possible coordination in the generation of IFN-mediated biological responses remain unknown. We ...