和 STAT3（Y705 和 S727）处于高磷酸化状态，而磷酸化 AKT（S473）和 ERK 1/2（T185/Y187）水平显著降低。这表明 SDS 患者体内这些信号通路存在异常调节，它们之间的相互作用可能对疾病的发生发展起到重要作用。 SDS 血浆和 LCLs 的分泌组特征：分析 SDS 患者血浆和 LCLs ...

no. ab207228) (Supplementary Materials). The levels of expressions of phosphorylated STAT3 (pSTAT3; Y705), pSTAT1 (pSTAT1; Y701), and pSTAT1 (S727) proteins were determined by Western blotting, ...

Bone remodeling involves a balance between bone resorption and formation. The mechanisms underlying bone remodeling are not well understood. DEF6 is recently identified as a novel loci associated with ...

2014). Signal transducer and activator of transcription 3 (STAT3) plays an important role in neural progenitor self-renewal and differentiation. As a member of the STAT family, STAT3 responds to ...

Moreover, both in vivo and in vitro results showed IH-induced cardiac fibroblast activation and increased TSP1 expression in cardiac fibroblasts. Mechanistically, phosphorylation of STAT3 at Tyr705 ...