Figure 1: Serine elastase inhibition induces survival by reversal of pulmonary hypertension. Inhibition of serine elastase activity reversed the progressive mortality of untreated or vehicle ...

Edited by Donald Ort, University of Illinois at Urbana Champaign, Urbana, IL; received December 10, 2024; accepted January 28, 2025 ...

7 Recent studies showed that sputum neutrophils in patients with bronchiectasis correlated with worse pulmonary function, bacterial colonisation, and disease severity due to excess proteases ...

School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Engineering Technology Research Centre for Functional ...

Medicinal Chemistry Research Group and National Drug Discovery and Development Laboratory, HUN-REN Research Centre for Natural Sciences, 2 Magyar tudósok krt, Budapest 1117, Hungary ...

Amino acids are the building blocks that form polypeptides and ultimately proteins. Consequently, they are fundamental components of our bodies and vital for physiological functions such as protein ...

In addition, we identified several phosphorylated serine and threonine residues, including the previously reported S80 and S421. We show that arginine methylation and to a much lesser extent also ...

Constrained, cyclic peptides encoded by plant genes represent a new generation of drug leads. Evolution has repeatedly recruited the Cys-protease asparaginyl endopeptidase (AEP) to perform their ...