Here, we showed that sunitinib induces a metabolic shift leading to increased serine synthesis in RCC cells. Activation of the GCN2-ATF4 stress response pathway was identified as the mechanistic link ...

Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing ...

This is a framework for RTL synthesis tools. It currently has extensive Verilog-2005 support and provides a basic set of synthesis algorithms for various application domains. Yosys can be adapted to ...

The team chose to focus on serine hydrolase, a much-studied enzyme that hydrolyses esters via four distinct mechanistic steps. The enzyme’s key structural features gave the team a clear design goal: ...

Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, College of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan 430061, China Institute for Safflower ...

Amphion (/æmˈfaɪən/) is a toolkit for Audio, Music, and Speech Generation. Its purpose is to support reproducible research and help junior researchers and engineers get started in the field of audio, ...

Leveraging the power of nature for sustainable chemical synthesis, utilizing enzymes as biocatalysts in chemical reactions can significantly accelerate product formation under mild reaction ...

The quality of the giant vesicles encapsulating a cell-free protein expression system was comparable to that of the ones formed using a conventional method, in terms of the synthesis of both soluble ...

Human serine racemase is a pyridoxal 5′-phosphate (PLP)-dependent dimeric enzyme that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to pyruvate and ammonia. As D ...

Certain serine codons, the four TCN codons, in the gene for the biofilm repressor SinR caused a lowering of SinR levels under biofilm-inducing conditions. Synonymous substitutions of these TCN codons ...