Objective We aimed to investigate the role of GPR171 in modulating CD4 + T cell effector functions in IBD and evaluate its therapeutic potential. Conclusions GPR171 deficiency promotes Th17 cell ...

为探究缺氧对奶牛乳腺上皮细胞（BMECs）乳汁合成的影响，研究人员开展相关研究，发现缺氧改变乳汁合成，为缓解奶牛乳腺缺氧应激提供靶点。 在生命的奇妙进程中，乳汁合成堪称一场能量密集的 “盛宴”，而氧气则是这场 “盛宴” 中至关重要的 “宾客 ...

The authors implement a valuable multi-tissue approach to dissect the physiologic consequences of JNK inhibition in parallel with dietary perturbation via sucrose. The conclusions of disrupted liver, ...

CXCR5 + memory Tfh cells in human blood are divided into Tfh1, Tfh2, and Tfh17 cells by the expression of chemokine receptors CXCR3 and CCR6 associated with Th1 and Th17, respectively. Here, we ...

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with gut microbiota disequilibrium and regulatory T (Treg)/T helper 17 (Th17) immune imbalance. Stigmasterol, a plant-derived sterol ...

In this review, we will discuss recent evidences that highlight the importance of Th cells in the efficacy of ICI therapy. Th1, Th2, Th9, Th17 and T follicular helper (T FH) cells have been broadly ...