Numerous mechanism and structural studies reported the cooperative role of Oct4 and Sox2 during the establishment of pluripotency during reprogramming. Due to the difficulty in sample collection and ...

之前的研究发现，雌性大鼠 VMN 的 GABA 能神经元会表达神经元型一氧化氮合酶（neuronal nitric oxide synthase，nNOS）的 mRNA，而且在胰岛素诱导的低血糖（insulin-induced hypoglycemia，IIH）情况下，位于 VMN 背内侧（VMNdm）和腹外侧（VMNvl）的 GABA 能神经元亚群，对 nNOS 转录的 ...

Here, we combine lattice light-sheet imaging, single-molecule tracking, numerical simulations, and ChIP-exo mapping to localize and functionally probe Sox2 enhancer-organization in living embryonic ...