The brain really is an incredible organ, and neurons are the vital link between, well, everything. The brain is anything but set in stone; how we think, feel, reason, and understand the world changes ...

Synaptic plasticity is the biological process ... The authors uncover slow, facilitating inhibitory connections between serotonin neurons in the dorsal raphe, refuting autoinhibition theories.

Theravance Biopharma, Inc. ("Theravance Biopharma" or the "Company") (NASDAQ: TBPH) today announced new analyses from its previous Phase 3 program evaluating ampreloxetine, an investigational medicine ...

First author Hamilton Oh, now at Icahn School of Medicine at Mt. Sinai, New York, and colleagues identified these potential markers during a proteomics analysis of CSF from 3,397 participants in six ...

Unfortunately, however, these agents are not universally available and only a minority of patients respond to them. Therefore, there is an urgent need to develop novel therapeutic strategies targeting ...

ABSTRACT: Alzheimer’s disease (AD) is highly prevalent in the elderly population and leads to AD patients’ higher mortality, low life quality, and lead to a huge economic burden on the health system.

Neuroscientists believe that synaptic plasticity, as these changes are called, plays an important role in storing memories. However, the rules governing when and how much synapses change are not ...

The device shows sound synaptic functions such as excitatory postsynaptic current (EPSC), inhibitory postsynaptic current (IPSC), and paired-pulse facilitation (PPF). With different spike amplitudes ...

The research team found that not only was RAS(ON) multi-selective inhibition effective in preclinical pancreatic cancer models, but it was even more effective when combined with immunotherapy.

This can include: being rude saying things that aren’t appropriate (for example, that someone is overweight) talking to strangers undressing in public apparent loss of sexual inhibition (for example, ...

Therefore, the direction and magnitude of gain and stability changes depend on the connectivity details of the inhibitory circuit. In the following sections, we dissect how firing rates and synaptic ...

However, recent findings have uncovered profound roles for synaptic inhibition in the processing of interaural time differences. In mammals, exquisitely timed hyperpolarizing inhibition adjusts ...