Catalyst Pharmaceuticals, Inc. ("Catalyst" or "Company") (Nasdaq: CPRX), a commercial-stage biopharmaceutical company focused on in-licensing, developing ...

This action results in the opening of slow voltage-dependent calcium (Ca2+) channels, allowing for a subsequent influx of Ca2+. In turn, it induces the exocytosis of synaptic vesicles containing ...

"Until our collaborative study, exocyst was understood to recognize and possibly tether secretory vesicles to the cell membrane, prior to exocytosis. In this study, we reveal biophysical studies ...

2012). In budding yeast, cell polarity and polarized exocytosis is coordinated also by the Rho3p GTPase (Adamo et al., 1999), which can regulate both actin polarity and transport of exocytic vesicles ...

Buchmann Institute for Molecular Life Sciences, Goethe-University, Frankfurt, Germany Institute for Biophysical Chemistry, Department of Biochemistry, Chemistry, and Pharmacy, Goethe-University, ...

SNX4 depletion did not affect vesicle recycling or the levels and localization of SNARE-protein VAMP2/synaptobrevin-2. However, SNX4 depletion affected synapse ultrastructure: an increase in docked ...

Synaptic vesicle docking and fusion are mediated by ... and neurotransmitter release by the Snapin peptides. Regulation of exocytosis is necessary for proper synaptic function.