Tet1/3 thus act as determinants of CD8 T cell fates by promoting chromatin accessibility at TCR-responsive genes during T cell development. Tet1/3 loss predisposes CD8 T cells to adopt short-lived ...

Delve into the landscape of biotech companies developing treatments for HIV and find out if we are getting closer to a cure.

推荐语：本研究揭示了TCR-pMHC-CD8三分子复合物在机械力调控下的"捕获-滑动"键动态特性，解决了高亲和力TCR工程中自身肽交叉反应性的难题。作者通过单分子生物力学、MD模拟等技术，发现CD8通过力依赖的构象变化增强TCR对激动肽的识别，而过度强化的TCR-pMHC结合 ...

T cells are a type of white blood cell that is central to your immune defense. Four types that serve different functions include: CD4 and CD8 are two different types of glycoprotein found on the ...

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders ...

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal ...

Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells and the relationship of both ...

TCR) and a sword or a bow (CD8). Optimization of both weapons and their cooperation will significantly strengthen the soldiers’ power. See page 265–283 by Rui Qin et al. for details.

在血液科临床中，区分T细胞增殖是“反应性”还是“克隆性”（即恶性）是诊断与治疗的关键。传统的分子检测（如TCR基因重排分析）虽被视为“金标准”，但耗时长、成本高。 多参数流式细胞术（MFC）的TCR-Vβ库分析更为快速和灵活。一项来自意大利的20年 ...

CERo Therapeutics (CERO) announces the allowance of two patent applications submitted to the U.S. Patent and Trademark Office, USPTO, which ...

The persistence of a similar TCR repertoire at postoperative endoscopy was associated with smoking and disease recurrence. Patients with high clonality showed increased expression of genes associated ...