to provide convincing evidence that two helper CD4 T-cell subsets, T-follicular helper (Tfh) and T-peripheral helper (Tph) cells, are able to drive both autoantibody production and induction of ...

New research shows antibiotics given at birth disrupt the infant microbiome, reducing key immune cells and increasing ...

While colorectal cancers (CRC) are paradigmatic tumors invaded by effector memory lymphocytes, the mechanisms accounting for the relative resistance of MSI negative CRC to immunogenic cell death ...

GC B cell, Tfh, Tph). The nearest neighbour distances from each Tph cell (n=57 994) or Tfh cell (n=2741), to either GC B cells or B cells were described further in Stata V.16 (StataCorp, Texas, USA), ...

The most well-characterized interactions between B cells and T cells occurs in the context of B cell antigen presentation to Tfh cells in secondary lymphoid organs. This facilitates B cell activation ...

Apr. 11, 2025 — A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments.

The following is a summary of “Evaluating the therapeutic potential of tofacitinib in Sjögren’s disease: a comprehensive ...

More information: Saumya Kumar et al, Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue, Cell Discovery (2024). DOI: 10.1038/s41421-024-00681-0 Provided ...