An immobilized signal manages to pass its message Four years ago, Cheng and co-senior author Stephen Nishimura, MD, discovered that TGF-Beta could signal to a receptor even when bound within its ...

Despite the high incidence of brain metastasis after resection of non-small cell lung cancer (NSCLC), the National Comprehensive Cancer Network guidelines do not recommend central nervous system (CNS) ...

The Tgfbr1 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type ... receptor proteins Tgfbr1, in a signaling pathway involved in various ...

Trial achieved key objectives for safety, tolerability, pharmacokinetics and pharmacodynamicsClinical data from this trial, ...

Endothelial cells are also likely to participate in activation, both by production of cellular fibronectin and via conversion of transforming growth factor (TGF)-beta from the latent to active ...

Most of my current research is in Alzheimer's disease and concerns the metabolism and clearance of soluble, insoluble and oligomeric forms of Abeta, alterations in Abeta-degrading enzymes, impairment ...

TGF-Beta is a pleiotropic cytokine expressed by almost every tissue and cell type, is stored in abundance in the extracellular matrix, and possesses suppressive and stimulatory signaling pathways.