An immobilized signal manages to pass its message Four years ago, Cheng and co-senior author Stephen Nishimura, MD, discovered that TGF-Beta could signal to a receptor even when bound within its ...

Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...

LEXINGTON, MA, USA I March 31, 2025 I Keros Therapeutics, Inc. (“Keros”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and ...

TGF-Beta is a pleiotropic cytokine expressed by almost every tissue and cell type, is stored in abundance in the extracellular matrix, and possesses suppressive and stimulatory signaling pathways.

Most of my current research is in Alzheimer's disease and concerns the metabolism and clearance of soluble, insoluble and oligomeric forms of Abeta, alterations in Abeta-degrading enzymes, impairment ...