Suppressing KCTD20 in both the organoids and mice prevented glutamate from triggering tau accumulation and neurodegeneration. Further experiments showed that blocking this gene’s activity activated ...

This study investigated the role of TIPE2 in regulation of CD4 + T lymphocyte function in interaction of PHSML and TLR2/TLR4. Methods: The splenic CD4 + T cells were isolated from various mice (WT, ...

Department of Rehabilitation Medicine, Qujing No. 1 Hospital, Qujing, China. To sum up, the objective of this research was to thoroughly explore SIRT1’s role and interplay in controlling microglial ...

Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, ...

Key Laboratory of Natural Products & Chemical Biology, Ministry of Education, Shandong University, Jinan 250012, P. R. China ...

Lysosome-related organelles (LROs ... As the LPS signal is mediated through TLR4 on DCs and macrophages, and these cells do not typically express granzymes, it will be interesting to unravel ...

We identify that Gal9 directly regulates BCR and distinct TLRs by binding to IgM-BCR and CD5 on the surface of B-1a cells as well as TLR4 and the regulatory molecule CD180, dampening signal ...

As the primary adenosine triphosphate-generating organelles, mitochondria are well-known regulators of stem cell fate decisions, yet it is now becoming apparent that additional organelles such as the ...

These mechanisms may serve as a checkpoint for the presence of the vacuole/lysosome. Animals, fungi and other eukaryotes have cells that are divided into sub-compartments that are called organelles.