The researchers measured nearly 40 percent less LAMP2, LIMP-2, GCase, and cathepsin B in the knockout cell lysosomes. These cells also cleaved prosaposin and progranulin less effectively. Progranulin ...

Lysosomal dysfunction is a common feature of several neurodegenerative diseases, including PD. The lysosome is the recycling center of the cell, responsible for breaking down waste material, old cell ...

Department of Chemistry, Shanghai Stomatological Hospital, State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences, Fudan University, Shanghai 200433, People’s ...

Epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, plays a vital role in increasing TLR4 cell surface expression and signal transduction in LPS-induced macrophages (15) ...

It can restrain the activation of the NF-κB/TLR4/NLPR3 signaling pathway, reduce the expression of downstream inflammatory factors, and mitigate inflammation. It can inhibit the caspase pathway, ...

同时，FMT 还通过抑制 TLR4/MyD88/NF - κB 信号通路，减轻了炎症反应。这些发现为肠道致病性冠状病毒的预防和控制提供了宝贵的见解，为开发新的防治策略奠定了理论基础，有望在未来的养猪业和公共卫生领域发挥重要作用。

After further analysis, the researchers found the drug relies on lysosomes, which are one of the cells' major recycling centers, and on an enzyme called cathepsin B. In Alzheimer's disease ...

After further analysis, the researchers found the drug relies on lysosomes, which are one of the cells' major recycling centers, and on an enzyme called cathepsin B. In Alzheimer's disease ...

According to the authors in Science Advances, this mechanism relies on a protein complex known as retromer and the lysosomes—cell organelles containing digestive enzymes. These special cellular ...