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TTR protein destabilised by TTR gene mutation is prone to dissociate from its native tetramer to monomer, and to then misfold and aggregate into amyloid fibrils, resulting in autosomal dominant ...

更有意义的是TTR在临床术后发生POCD的患者外周血中也显著低于没有发生POCD的老年手术患者。进一步的表达和功能研究发现，TTR主要定位于小鼠中枢 ...

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Hereditary transthyretin amyloid (ATTRv) cardiomyopathy (CM) is caused by mutations in the TTR gene. TTR mutations contribute to TTR tetramer destabilization and dissociation, leading to excessive ...

Figure 1. Pathogenesis and clinical manifestations of ATTR amyloidosis. Wild-type and mutant TTR are produced and secreted into the blood or cerebrospinal fluid (CSF) as tetrameric proteins. Mutations ...