In AD, p-tau181 and p-tau217 appear to come from the brain, since these markers rise in the CSF as well as blood. Neither p-tau showed up in ALS CSF. However, immunostaining identified p-tau181 and ...

Institute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan Institute of Biochemical Sciences, National Taiwan ...

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...

Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...

USC Stem Cell scientists discover a new way to rid cells of toxic tau protein in a study involving mice and lab-grown human “mini-brains,” known as organoids. The neurotransmitter glutamate is ...

Get Instant Summarized Text (Gist) Glutamate, a neurotransmitter, can lead to a toxic buildup of tau protein, contributing to Alzheimer's and related diseases. Research using lab mice and human ...

How to clear the toxic tau protein that can lead to Alzheimer's and related diseases Date: March 5, 2025 Source: Keck School of Medicine of USC Summary: The neurotransmitter glutamate is essential ...

Hormone therapy (HT) in women over 70 is linked to faster tau accumulation, a marker of Alzheimer's disease, especially if initiated more than a decade prior. No significant difference in amyloid ...

However, research has also linked glutamate to the toxic accumulation of tau protein – a hallmark of neurodegenerative diseases like Alzheimer’s. A recent study led by scientists at USC Stem Cell, ...

In AD and in FTD, hyperphosphorylation of tau protein causes its misfolding and aggregation. Again, our understanding of the precise consequences of tau phosphorylation in the biology and ...

[Editors' note: this paper was reviewed by Review Commons.] We found that rG4 immunostaining strongly increased in the hippocampus with both age and with AD severity. We further found that neurons ...