A study from the University of Cologne has provided new insights into how the tau protein contributes to Alzheimer’s disease. Using human induced pluripotent stem cells (iPSCs), researchers identified ...

Using a novel quantitative chemoproteomic strategy, a research group led by Prof. Wang Chu from the College of Chemistry and ...

Tau is a microtubule-associated protein that ... In addition, animal models that closely mirror the initiation and progression of human tauopathies have so far been lacking. Researchers at the ...

Activating stem cells via molecular programming, rather than relying on random cell transplants, significantly enhances the success of regenerative treatments.

In this new study, the research team developed a nasal spray with the ability to clear tau proteins from the brains of mice engineered to have human-like Alzheimer's symptoms. The researchers ...

Antibodies specific to tau’s mid-section or MTBR/R’ regions stymied anti-synaptic activity of these preparations. Strikingly, the injected human tau lingered in the rat hippocampus for three weeks ...

The research group led by Prof. Wang Chu from the College of Chemistry and Molecular Engineering at Peking University ...

Using human induced pluripotent stem cells (iPSCs), the international team has been able to show that a specific form of the tau protein, known as the 1N4R isoform, is responsible for mediating ...

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction. Alzheimer's & Dementia , 2025 DOI: 10. ...