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CRISPR/Cas9 技术揭示 PD-L1 在银屑病小鼠模型免疫调节中的关键作用:为 ...
为探究 PD-L1 对银屑病进展的影响,研究人员构建 PD-L1 基因敲除(PD-L1 KO )和过表达(PD-L1 OE )小鼠模型 ... 以往认为其与辅助性 T 细胞 1(Th1)有关,后来发现白细胞介素(IL)-23 刺激 γδT 细胞和 Th17 细胞,形成 IL-23/Th17 的正反馈循环,在发病中起关键作用。
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