Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy ...

Abnormal disulfide bonds are formed in actin cytoskeleton proteins, and F-actin is broken down, ultimately leading to disulfidptosis. Moreover, depletion of NADPH can also hinder GSH/GSSG conversion ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Significant advancements have recently been achieved in the ...

Medically reviewed by Beth Thomas, PharmD Glutathione (GSH) is an antioxidant naturally produced by the liver and central ...

Cells produce many protein molecules. These are made of chains of building blocks called amino acids that then fold into three-dimensional shapes. Specialist proteins known as chaperones assist this ...

Newly made proteins are unstructured chains of amino acids that must fold into particular shapes to work effectively. Proteins that are destined to be exported from the cell undergo folding in a ...

To confirm that the primary mechanism was through the SNO-Hb pathway, aortic rings from eNOS knockout mice (to eliminate the direct effect of ATP, NOS, and nitrite) were used to assess vasodilation at ...

The reversible conversion of reduced to oxidized form may also rapidly modify the GSH pool. The interaction and exchange reactions of low-molecular-weight thiols and cysteines of plasma-membrane ...