在肿瘤微环境中，调节性T细胞（Tregs）早已被视为抗肿瘤免疫系统的“叛徒”。尽管我们明白Tregs在抑制免疫反应方面的作用，但它们如何具体实现这一点仍然是一个谜。最近，NoyesD等研究者通过对小鼠模型及人类样本进行深入研究，揭示了Tregs如何通过双重机制，即抑制共刺激信号及剥夺白细胞介素-2（IL-2），来导致CD8+T细胞的功能障碍和克隆多样性的受限。

T细胞作为对抗感染的第一线战士，一直是研究的主要焦点。调节性T细胞（Tregs）是一种特殊的免疫细胞，肩负着在体内维持免疫平衡的艰巨任务。它们必须确保免疫系统既足够强大以对抗感染和癌症，又不会过度反应而攻击身体的正常细胞。Tregs通过控制其他 ...

Regulatory T cells (Tregs) have gone from obscurity to rock-star status in the past decade, prompting intense scrutiny—but what exactly are they? Four studies examine this question, delving ...

Lupus is an autoimmune disease where the body's immune system attacks its own tissues and organs, causing inflammation and damaging organs. A new study has now shown that the natural active ingredient ...

Systemic lupus erythematosus, or lupus, is a complex autoimmune disease in which the immune system mistakenly attacks healthy ...

Previous studies on regulatory T-cell (Treg) reconstitution after allogeneic hematopoietic SCT (HSCT) have suggested that, within the GVHD process, imbalance between effector T cells and Tregs may ...

A team has developed scSPOT, a new technique that reveals how immune cells called Tregs simultaneously control the immune system. The team identified key immune cells controlled by Tregs and found ...

Derived from scRNA-seq, SLC26A3 is a potential therapeutic target to improve the efficacy of immunotherapy, as well as a potential diagnostic indicator to reduce post-surgical upstaging, for cervical ...

Regulatory T cells (Tregs) are specialized immune cells that have a challenging task in the body. They must balance the immune system by making it aggressive enough to fight infection and cancer ...