It examines how the mechanical stiffness of the extracellular matrix (ECM), a network of proteins that surrounds cells and tissues in the body, impacts tumor development. "Tumors evolve through a ...

The researchers found that the treatment that included sulfuretin and two synthetic compounds altered the function of a ...

The researchers designed an efficient approach for fabricating engineered Pts-based nano-aircraft carriers with graded drug ...

Tumors are held together by a structure called the extracellular matrix (ECM) that acts like the scaffolding around a building under construction. A team from The Institute of Cancer Research ...

Understanding the molecular cross-talk that occurs within the microenvironment between tumor cells and the ECM/other stromal cells may point to opportunities for cotargeting of the tumor and ...

Non-cancer cells exist alongside the cancerous ones in the extracellular matrix (ECM), which is a network of different molecules in all tissues and organs that provide structure for the cells. The ECM ...

"Our work focused on fundamental understanding of ultrasound-mediated cancer cell killing and the effect of the ECM binding spacing on it," explains S Manasa Veena, Ph.D. student in BE and first ...

“Our work focused on fundamental understanding of ultrasound-mediated cancer cell killing and the effect of the ECM binding spacing on it,” explains S Manasa Veena, PhD student in BE and first ...

Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy ...

PYX-201 is a first-in-concept antibody-drug conjugate (ADC) that uniquely targets Extradomain-B Fibronectin (EDB+FN), a non-cellular structural component within the tumor extracellular matrix (ECM), ...