本文深入探讨了CD8 + T细胞在肿瘤进展和慢性病毒感染中因持续抗原刺激导致的功能障碍（如耗竭exhaustion），并揭示了其他潜在机制（如耐受tolerization、失能anergy、衰老senescence等）。作者提出整合性研究框架，为开发靶向T细胞功能障碍的癌症和慢性感染治疗策略 ...

Two new studies in Nature report on how effector memory-like CD8 + T cells infiltrate inflamed tissues in various disease states and drive tissue-restricted complement activation via the release ...

What weighs 80 pounds, relies on a daily diet of beef, deer and horse meat, and displays a distinctly snowy fur coat? The answer, according to the Texas-based Colossal Biosciences, is a six-month ...

1Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China. 2Department of Head and Neck Oncology, State Key Laboratory of ...

Bluebird Bio and Xcellbio have entered into an agreement to support the commercialization of Lyfgenia (lovotibeglogene autotemcel), Bluebird’s gene therapy for sickle cell disease, incorporating ...

they examined the genes that were expressed in each cell type and the regulatory elements that control gene activity. Advanced single-cell analysis techniques revealed three key changes in the ...

The company was originally formed with a primary focus on the research of emerging classes of medicines like cell and gene therapies ... and its employees—isn't a complete surprise.

Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...

The global cell and gene therapy market is projected to witness significant growth in the coming years. By 2035, the market size is projected to increase from approximately USD 20.5 billion in 2024 to ...

为探究宿主效应 CD4 + T 细胞能否被过继转移的 CD8 + T 细胞激活，研究人员开展了相关研究。结果发现小鼠肿瘤特异性 Tc9 细胞可招募并激活宿主效应 CD4 + T 细胞控制抗原缺失复发肿瘤。该研究揭示了体内激活肿瘤特异性 CD4 + T 细胞的机制。 宿主效应 CD4 + T 细胞是 ...