A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

An enzyme called Ubiquitin-specific peptidase 5 is a key factor in protein quality in heart muscle cells ...

An enzyme called Ubiquitin-specific peptidase 5 is a key factor in protein quality in heart muscle cellsA disrupted protein ...

Bacterial and viral infections activate the signal transduction networks that regulate the innate immune system, and trigger the production of inflammatory mediators to combat these pathogens.

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of ...

As of September 30, 2024, Alector had $457.2 million in cash, cash equivalents, and investments, which the company continues to expect will provide runway through 2026. Alector plans to provide ...

The activation of ubiquitin-mediated proteolysis resulted in PDE9A degradation ... Granule cells, which are pervasively distributed within the hippocampus and cerebellum and are instrumental in ...

Our data also provide clues to biological function for hundreds of previously uncharacterized human genes. We set out to identify cell-cycle–regulated transcripts in human cells on a genome-wide ...

These findings suggest that non-lysine ubiquitination rivals the regulatory sophistication of its conventional counterpart and might serve distinct cellular functions. The reversibility of ...