UbiREAD: Cracking the ubiquitin code of protein degradation
Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming ...
Nature2y
Ubiquitin and the Biology of the Cell
Ubiquitin and the Biology of the Cell, as the editors note, is published 10 years after the first book on ubiquitin appeared and 23 years after the first biochemical description of this ubiquitous ...
Nature1y
The ubiquitin system
Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system. As indicated before 19, the main lesson from our story is the continued importance of the use ...
Dual protein tagging process could lead to new treatments for immune system diseases
A study by Oregon Health & Science University researchers has uncovered a new way proteins can be changed inside cells. This ...
EurekAlert!9d
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, ...
EMBO Press12d
A new hybrid post-translational modification—have you lost your (MARUb)les?
Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...
Informationsdienst Wissenschaft8d
Cracking the Code of Protein Degradation
Researchers at the Max Planck Institute of Biochemistry (MPIB) have developed the new UbiREAD technology to decode the various combinations of ubiquitin molecules – the ubiquitin code – which ...