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细菌性肺炎引发肺泡巨噬细胞更替机制:衰老与竞争的新视角
本文聚焦肺泡巨噬细胞(AMs),利用肺炎链球菌(S.P.)感染小鼠模型展开研究。发现 S.P. 感染诱导单核细胞来源的 AMs 产生,且感染后组织驻留 AMs(TRAMs)出现衰老,增殖能力下降,被单核细胞来源的 AMs(MoAMs)取代。这为肺部细菌感染时 AMs 更替机制及功能 ...
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