Canonical Wnt signaling regulates bone formation and is essential for osteoblast proliferation, differentiation, function and survival. Antiresorptive agents are the mainstay of current ...

在细胞核内，β-catenin激活下游基因如c-Myc和Cyclin D1，促进细胞增殖和存活。 在HCC中，Wnt通路关键组分的突变，包括β-catenin（由CTNNB1编码）、AXIN和APC，导致该通路持续激活。这种失调通过增强细胞增殖、迁移和免疫逃避来驱动HCC的进展。此外，已经发现细胞外囊 ...

In HCC, mutations in key components of the Wnt pathway, including β-catenin (encoded by CTNNB1), AXIN, and APC, lead to sustained activation of this pathway. This dysregulation drives HCC progression ...

In HCC, mutations in key components of the Wnt pathway, including β-catenin (encoded by CTNNB1), AXIN, and APC, lead to sustained activation of this pathway. This dysregulation drives HCC ...

The figure on the left shows the deactivation of the Wnt pathway. In the absence of Wnt signaling, β-catenin in the cytoplasm is recognized, folded, and phosphorylated by a destructive complex ...

Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here ...

The factors in the TME and signaling networks that program DCs to a regulatory state are not fully understood. Recent advances point to novel mechanisms by which the canonical Wnt signaling cascade in ...

The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. Different pathways diverge at this point by a mechanism that remains ...