Introduction: Understanding the molecular mechanism underlying the pathogenesis of knee osteoarthritis (KOA) may be beneficial in fetching new therapeutics. Our study aims to investigate the ...

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

1Key Laboratory of Receptors-Mediated Gene Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, China.

来自山东青岛的研究团队针对Wnt信号通路基因变异与轻度认知障碍（MCI）的关联机制展开研究，通过分析459名老年人数据发现PRKCA-rs2286674等SNP与MCI显著相关，首次揭示血脂对PRS（多基因风险评分）效应的修饰作用，并构建随机森林预测模型，为阿尔茨海默病早期 ...

Wnt signaling plays key roles in oncogenic transformation and progression in a number of cancer types, including tumors in the breast, colon, ovaries, liver, and other tissues. Despite this importance ...

On the occasion of the 30th anniversary of the discovery of the first mammalian Wnt-gene, this Focus issue features a personal perspective from Roel Nusse and Harold Varmus on past, current and future ...

This important study investigates the function of a critical regulator of human early cardiac development. The convincing examination of GATA6 function is thorough and well-executed. The study will be ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

Thus, understanding the molecular mechanisms driving HCC is essential for developing new therapeutic strategies. A growing body of research highlights the crucial role of the Wnt signaling pathway ...

(A) Bar plot of IARS2 transcription level in different cancer types. (B) TCGA and GTEx databases showed IARS2 transcription level was higher in tumor tissue compared with normal pancreas tissue.