Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming ...

Hypospadias is characterized by an ectopic urethral opening and abnormal penile curvature, affecting approximately 1 in 200 live male births.

A recent study has unveiled the critical roles of two transcription factors, MAFB and CEBPA, in the development of ...

Genetics and Molecular Biology considera contribuições que apresentem os resultados de pesquisas originais nas áreas de genética, evolução e disciplinas científicas relacionadas. Genetics and ...

"We found that organoids bearing MYC on extrachromosomal DNA could shift their dependency on WNT," explains Antonia Malinova ...

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common congenital condition that ...

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide, with approximately 20% of patients presenting with metastatic disease at the time of diagnosis. Despite the ...

Competing interests SYL and STY have received research sponsorship from Pfizer, Merck, Servier and Curegenix. HC is an inventor on several patents relating to Wnt activity in cancers and a pending ...

On the occasion of the 30th anniversary of the discovery of the first mammalian Wnt-gene, this Focus issue features a personal perspective from Roel Nusse and Harold Varmus on past, current and future ...