We found that the three DNA-damaging drugs, namely Nutlin, Doxorubicin, and 5-Fluorouracil (5-FU), stabilized p53 and concurrently repressed BLM and RAD51 in both HCT116 WT and HCT116 p21−/− cells but ...

Among those genes, TP53 (encoding the p53 protein) has been identified as the most frequently mutated gene that causes cancer ...

此前已证实阿霉素（ADR）可诱导小鼠足细胞衰老。为进一步探究这一过程的机制，研究了雷莫丁（Remodelin）处理后肾小球中衰老相关蛋白的变化。蛋白质印迹（WB）分析显示，雷莫丁可减轻阿霉素诱导的 P53、P21、P16 ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Gene therapy holds great promise as a therapeutic approach for combating cancer, with ...

Ways to gain weight with a fast metabolism include increasing caloric intake, eating more often, choosing healthy fats, and more. Metabolism is the rate at which you expend energy and use calories. A ...

What Is an Ideal Body Weight? Ideal weight is different for everyone. Doctors use weight as one benchmark for health. A “healthy weight range” is based on various factors unique to you ...

Mattress weight capacity determines which body types can comfortably use a mattress without sacrificing support or reducing the longevity of your bed. The standard mattress weight limit is around ...

The Ultimate Fighting Championship introduced two weight classes at UFC 12: Heavyweight, which had competitors above 200 lb (91 kg), and Lightweight, which grouped competitors under 200 lb.