Objectives In this study, we employ a multiomic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine ...

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...

After four days, Mobile World Congress has come to an end. During our time in Barcelona, we saw countless phones, wearables, AI implementations and gadgets on display.

这些发现为改写临床实践带来曙光——从预测cGAS阳性微核的早期诊断标志，到针对TCF4-ZEB1轴的精准治疗策略，我们终于获得拦截这场"细胞大迁徙"的 ...

为探究 ZEB1 在根尖周炎中的作用，研究人员检测其表达，发现它与 Th17 细胞及 p-STAT3 相关，助力治疗研究。 根尖周炎，这个在口腔健康领域并不陌生的 “捣蛋鬼”，常常让患者饱受疼痛折磨。它是一种源于牙根尖周围组织的常见炎症性疾病，根尖肉芽肿 ...

IFNγ treatment of luminal MIBC cell lines significantly decreased the expression of luminal transcriptional drivers, including FOXA1, and increased the expression of Ba/Sq markers in a STAT1-dependent ...

This inhibition results in an impaired nuclear translocation of the interferon-stimulated gene factor 3 (ISGF3) complex, as well as in the proteasome-dependent STAT2 degradation and caspase ...

Background: Germline mutations in signal transducer and activator of transcription 1 (STAT1), which lead to primary immunodeficiency, are classified as defects in intrinsic and innate immunity. To ...

Bone remodeling involves a balance between bone resorption and formation. The mechanisms underlying bone remodeling are not well understood. DEF6 is recently identified as a novel loci associated with ...