Department of Oral Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai ...

As a vertebrate, the zebrafish possesses many genes that perform the same or similar functions in mammals and therefore also in humans. Approximately 70 percent of zebrafish genes are also present in ...

The authors provide valuable insights into the candidate upstream transcriptional regulatory factors that control the spatiotemporal expression of selector genes and their targets for GABAergic vs ...

Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature ...

体外实验显示，ZSH-512对CRC干细胞（TRCs）的IC 50 值（1.0-3.0 μM）显著低于普通CRC细胞（4.6-10.4 μM），且能剂量依赖性下调CD133、SOX2等干性标志物表达。 ??多模型验证抗肿瘤效果?? 在3D软纤维蛋白凝胶培养模型中，ZSH-512（5 μM）处理24小时后洗脱，仍可持续抑制TRCs ...

推荐阅读：本文利用双重组酶介导的遗传系统追踪 Brachyury + Sox2 + 神经中胚层祖细胞（NMPs）。研究发现 NMPs 由不同祖细胞群构成，具有双潜能性，对胚胎躯干和尾部发育至关重要，为相关研究提供了重要依据。 ### 研究背景 在胚胎发育过程中，神经中胚层祖细胞 ...

Researchers have identified secretoneurin, a neuropeptide derived from the secretogranin-2 protein, as a critical hormone that stimulates ovulation in zebrafish. This finding has significant ...

Researchers have identified secretoneurin, a neuropeptide derived from the secretogranin-2 protein, as a critical hormone that stimulates ovulation in zebrafish. “Using a novel biochemical ...

Genes such as Sox2 and Foxj1 are enriched in the proximal airways, while Sox9 and Etv5 are more prominent in the distal regions. Notably, two alveolar niches (D2 and D7) exhibited divergent ...